Amlodipine vs. Amlodipine Besylate: What's the Difference?

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Amlodipine and amlodipine besylate are commonly prescribed medications for managing high blood pressure and angina, a type of chest pain caused by reduced blood flow to the heart. Despite their similar names, there is often confusion about their differences and similarities. This article will clarify these differences, explain how each medication works, and discuss their benefits and side effects.

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Understanding Amlodipine and Amlodipine Besylate

Both amlodipine and amlodipine besylate belong to a class of medications known as calcium channel blockers. They work by relaxing the blood vessels, which allows blood to flow more easily, thereby lowering blood pressure and reducing chest pain (angina).

Amlodipine is the generic name of the drug, whereas amlodipine besylate is the besylate salt form of amlodipine. Essentially, amlodipine besylate is the chemical form in which amlodipine is most commonly prescribed and available.

Uses of Amlodipine and Amlodipine Besylate

These medications are primarily used to treat:

• Hypertension (High Blood Pressure): By relaxing the blood vessels, they help lower blood pressure, reducing the risk of strokes, heart attacks, and kidney problems.

• Angina (Chest Pain): They help prevent chest pain by improving blood flow to the heart muscle, allowing it to receive more oxygen.

How They Work

Amlodipine and amlodipine besylate function by inhibiting the influx of calcium ions into the smooth muscle cells of the heart and blood vessels. This action prevents the blood vessels from constricting, allowing them to remain relaxed and dilated. As a result, blood pressure decreases, and the heart's workload is reduced, which can alleviate angina.

Dosage and Administration

Amlodipine and amlodipine besylate are typically taken once daily, with or without food. The dosage may vary based on the individual's condition and response to treatment. Common starting doses range from 5 mg to 10 mg per day.

Side Effects

Common side effects of amlodipine and amlodipine besylate include:

• Swelling of the ankles or feet (edema)

• Dizziness or lightheadedness

• Flushing

• Fatigue

In rare cases, more severe side effects can occur, such as:

• Increased chest pain or heart attack

• Severe dizziness or fainting

• Irregular heartbeat

Effectiveness

Both amlodipine and amlodipine besylate are effective in managing hypertension and angina. The besylate salt form (amlodipine besylate) is commonly used because it is more stable and has a longer shelf life, making it easier to store and use.

Comparing Amlodipine and Amlodipine Besylate

While the active ingredient in both medications is the same, the difference lies in the salt form used to deliver the drug. Amlodipine besylate is simply a more stable form of amlodipine, which does not affect the efficacy of the medication. Therefore, whether you are prescribed amlodipine or amlodipine besylate, the therapeutic outcomes should be the same.

Cost and Accessibility

Amlodipine besylate is widely available as a generic medication, making it an affordable option. To further reduce costs, you can use a discount prescription card, like CareCard, to help make medications more cost-effective. 

Choosing the Right Medication

When deciding between amlodipine and amlodipine besylate, the primary consideration is usually based on availability and cost rather than differences in efficacy or side effects. Always consult your healthcare provider to determine the best treatment plan for your condition.

Conclusion

While amlodipine and amlodipine besylate are often used interchangeably to treat high blood pressure and angina, understanding their subtle differences can be crucial for those using them and healthcare providers alike. Amlodipine is the active ingredient, whereas amlodipine besylate refers to the specific salt form used to deliver the medication effectively. This distinction does not impact the therapeutic efficacy or the way the drug works in the body, but it can be relevant in terms of formulation and prescribing information. 

Understanding the differences between them can help you make informed decisions about your treatment. Remember to consult with your healthcare provider for personalized medical advice.

For those looking to manage medication costs, consider using a discount prescription card. CareCard can help you save on prescriptions at over 80,000 pharmacies nationwide, ensuring you can access the medications you need.

FAQs

Q: Are amlodipine and amlodipine besylate the same? A: Amlodipine besylate is the besylate salt form of amlodipine. Both have the same active ingredient and therapeutic effects.

Q: What are the common side effects of amlodipine and amlodipine besylate? A: Common side effects include swelling of the ankles or feet, dizziness, flushing, and fatigue.

Q: Can I use a discount prescription card for amlodipine besylate? A: Yes, a discount prescription card can help reduce the cost of amlodipine besylate prescriptions.

Q: How does amlodipine help with high blood pressure? A: Amlodipine relaxes and widens blood vessels, allowing blood to flow more easily, thereby lowering blood pressure.

Q: How should I take amlodipine? A: Amlodipine is usually taken once daily, with or without food. Follow your healthcare provider's instructions regarding dosage.