May 31, 2023




Buspirone vs. Xanax: Understanding the Differences and Choosing the Right Medication for You

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Finding the right medication for managing anxiety and related conditions can be overwhelming, especially if it's not relieving your symptoms effectively. 

In these cases, your healthcare provider may prescribe an additional drug to take with an antidepressant, such as Buspirone or Xanax (Alprazolam)

We'll dive into the conditions each medication can treat, dosage guidelines, how they work, as well as their potential side effects, precautions, and interactions. By understanding these factors, you'll be better equipped to have an informed discussion with your healthcare provider to find the best medication that meets your needs.

Find the lowest price for Buspirone and Xanax here and get free instant savings coupons for your local pharmacy here.  No insurance or sign up is required.

Conditions Treated

Both Buspirone and Xanax (alprazolam) are medications commonly prescribed to treat anxiety-related conditions. 

Buspirone is primarily used for generalized anxiety disorder (GAD). In addition, it's sometimes prescribed off-label to treat depression, substance abuse, post-traumatic stress syndrome (PTSD), bruxism (teeth grinding), and tardive dyskinesia (TD). It provides long-term anxiety management with minimal sedation and addiction risk. 

On the other hand, Xanax is commonly prescribed for anxiety and panic disorder. Healthcare providers may recommend it off-label for insomnia, depression, Premenstrual Dysphoric Disorder (PMDD), alcohol withdrawal, and prolonged seizures. It offers more immediate relief from acute anxiety symptoms but carries a higher risk of sedation and dependence.


The typical starting dosage of Buspirone is 5 mg, taken twice daily. Depending on your response and tolerability, the dose may gradually increase up to 60 mg daily.

The initial Xanax dosage varies depending on the treated condition and your response. It's typically prescribed in lower doses, such as 0.25 mg to 0.5 mg, taken three times a day. Dosages may be adjusted as needed but should only be done under medical supervision.

How they work 

Buspirone is in the anxiolytics medication class and works by affecting serotonin receptors in the brain. It's known for providing calming effects without causing significant sedation or addiction potential. However, it may take several weeks for you to notice the full therapeutic effects. 

Xanax belongs to the class of medications called benzodiazepines, which enhance the effects of  a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain. It has a rapid onset of action, providing immediate relief from anxiety symptoms. 

Precautions and Interactions

Before starting new medicines, you should review your current medications and medical history with your doctor. 

Buspirone may not be suitable for individuals with liver or kidney impairment. To avoid severe interactions, this drug shouldn't be used if you're taking certain medications, such as monoamine oxidase inhibitors (MAOIs), like Phenelzine (Nardil), Selegiline (Emsam), and Tranylcypromine (Parnate)

Xanax should be used with caution if you have a history of substance abuse, respiratory conditions, or liver impairment. It can also interact with other medications, including opioids, alcohol, and certain antidepressants, leading to increased sedation and respiratory depression.

Side Effects

Common side effects of Buspirone may include dizziness, headache, nausea, and nervousness. It is generally well-tolerated, with a lower risk of sedation and cognitive impairment compared to benzodiazepines.

Xanax also has potential side effects, including drowsiness, dizziness, and coordination difficulties. It may also cause memory problems, confusion, and paradoxical reactions (opposite effects of what the medication is supposed to do).

Which one works the best?

Buspirone and Xanax are both effective for treating anxiety symptoms. When considering either medication, it's important to discuss your specific symptoms, medical history, and preferences with your healthcare provider. 

Buspirone offers an alternative for individuals seeking long-term anxiety management with minimal sedation and addiction risk. Xanax, on the other hand, may provide more immediate relief for acute anxiety symptoms but carries a higher risk of sedation and dependence. 

By working closely with your healthcare provider, you can find the medication that helps you manage your anxiety effectively and safely. 

At CareCard, we are passionate about helping make your prescription payments more affordable, saving members up to 85% on prescription drugs and medications. You can search for antidepressant medication coupons here and learn how CareCard can help make your medication payments more manageable.

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