Sep 29, 2023



Can I Take Ibuprofen And Percocet Together?

ibuprofen and percotet

Always seek advice from your healthcare provider before starting any new medication regimen.

When pain strikes, finding effective relief becomes a top priority. Among the commonly prescribed pain medications are ibuprofen and Percocet, each with its own unique pain-relieving properties. But can you take both medications together for more comprehensive pain management? 

In this blog post, we'll explore what you need to know about taking ibuprofen and Percocet together, from potential interactions between the drugs to side effects you may experience. So if you're considering combining these medications, read on for important information.

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Is It Safe to Take Ibuprofen and Percocet Together?

Combining ibuprofen and Percocet is generally not recommended without consulting a healthcare professional. Both medications belong to different classes: ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID), while Percocet is an opioid pain reliever. Their combination may lead to increased side effects and potential health risks. Therefore, it's essential to seek medical advice before using these medications together.

Ibuprofen Onset Time:

The time it takes for ibuprofen to start working can vary. Typically, ibuprofen begins to alleviate pain within 30 minutes to an hour after ingestion. However, individual responses to this medication can differ, and it's essential to follow your healthcare provider's instructions for dosing and timing when taking ibuprofen.

Percocet Onset Time:

In the case of Percocet, the onset of its effects may differ as well. Generally, Percocet's effects are usually felt within 30 to 60 minutes after ingestion. As with ibuprofen, individual responses to Percocet can vary, so it's crucial to adhere to your healthcare provider's recommendations for dosing and timing when using this medication.

Can I Take Ibuprofen and Percocet Together if I Have Liver Problems?

Individuals with liver problems should exercise caution when considering the combination of ibuprofen and Percocet. Both medications can impact liver function, and their simultaneous use may exacerbate liver-related issues. It's vital to inform your healthcare provider about any liver conditions to determine the safest pain relief approach.

When to Avoid the Combination

Avoid combining ibuprofen and Percocet if you have a history of allergic reactions to either medication or other opioids. Additionally, individuals with a history of substance abuse or respiratory problems should avoid this combination due to the potential risks.

Possible Interactions

Taking ibuprofen and Percocet together may lead to drug interactions. Both medications can cause drowsiness and respiratory depression as side effects. Combining them can intensify these effects, which may be dangerous. Always consult your healthcare provider before combining these medications to minimize the risks.

Taking Ibuprofen and Percocet During Pregnancy

If you are pregnant or planning to become pregnant, avoid using ibuprofen and Percocet without medical guidance. These medications may pose risks to the developing fetus, and alternative pain relief options should be explored under the supervision of a healthcare professional.

Over-The-Counter Ibuprofen With Prescription Percocet

It is generally not recommended to take over-the-counter ibuprofen with prescription Percocet without proper medical advice. Combining different pain medications may lead to unpredictable interactions and increased risks of side effects.

Dosage and Frequency: Ibuprofen and Percocet

While there are drug information sheets, it is always essential to consult your attending healthcare provider for the proper dosage and frequency of taking ibuprofen or Percocet, as medication treatment may vary depending on an individual's condition and pain intensity. Always follow their prescribed dosing schedule to ensure safe and effective pain management.

If you suspect an accidental overdose or encounter any adverse reactions after taking these medications, it's essential to seek immediate assistance from a poison control center or medical professional.

Taking Ibuprofen and Percocet When Breastfeeding

If you are breastfeeding, avoid using ibuprofen and Percocet without consulting a healthcare professional. These medications may pass into breast milk and potentially affect the nursing infant. Discuss alternative pain relief options suitable for breastfeeding mothers with your healthcare provider.


Generally speaking, combining ibuprofen and Percocet is not recommended for routine pain relief. Therefore, as a general rule of thumb, always talk to your doctor or pharmacist before mixing any medications. With their knowledge of your health history and unique situation, they can provide tailored advice regarding the risk/benefit analysis associated with taking ibuprofen and Percocet together.

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