Jun 20, 2023




Losartan vs Lisinopril: A Comparative Analysis

A nurse checking a patient's blood pressure

When it comes to managing hypertension, two commonly prescribed medications are Losartan and Lisinopril. Both drugs belong to a class of medications known as angiotensin-converting enzyme (ACE) inhibitors, which are used to treat high blood pressure and other related conditions. In this article, we will compare Losartan and Lisinopril in terms of their effectiveness, side effects, and other important factors to help you understand the differences between them and make an informed decision.

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Always seek advice from your healthcare provider before commencing any new medication regimen.

Mechanism of Action

Losartan and Lisinopril work in slightly different ways to lower blood pressure. Losartan is an angiotensin II receptor blocker (ARB) that blocks the action of a hormone called angiotensin II, which causes blood vessels to narrow and constrict. By blocking the effects of angiotensin II, Losartan helps relax and widen the blood vessels, reducing blood pressure.

On the other hand, Lisinopril is an ACE inhibitor that prevents the conversion of angiotensin I to angiotensin II. By inhibiting this conversion, Lisinopril reduces the levels of angiotensin II in the body, leading to relaxation and widening of blood vessels, thus lowering blood pressure.

Can Losartan and Lisinopril be taken together?

Combination therapy with Losartan and Lisinopril is generally not recommended unless prescribed by a healthcare professional.

Can Losartan or Lisinopril be used during pregnancy?

Both Losartan and Lisinopril are not recommended during pregnancy as they can harm the developing fetus. Pregnant individuals should consult their healthcare provider for alternative treatment options.


Both Losartan and Lisinopril are effective in treating hypertension and reducing blood pressure. However, individual responses to medications may vary. Some people may respond better to Losartan, while others may find Lisinopril more effective. It is important to consult with your healthcare provider to determine which medication is most suitable for you based on your specific medical condition.

Side Effects

Like any medication, Losartan and Lisinopril may cause side effects. Common side effects of Losartan include dizziness, fatigue, cough, and gastrointestinal disturbances. Lisinopril may also cause similar side effects, along with a dry cough, rash, and changes in taste sensation. It is crucial to discuss any potential side effects with your doctor, as they can provide guidance on managing them or suggest alternative medications if necessary.

Dosage and Administration

The dosage of Losartan and Lisinopril may vary depending on individual factors such as age, medical history, and the severity of hypertension. Both medications are available in different strengths and formulations. It is important to follow your doctor's instructions regarding dosage and administration to ensure optimal results and minimize the risk of side effects.

Drug Interactions

Both Losartan and Lisinopril can interact with other medications, including over-the-counter drugs and herbal supplements. It is crucial to inform your healthcare provider about all the medications and supplements you are currently taking to avoid potential interactions that may affect the effectiveness or safety of Losartan or Lisinopril.


The cost of Losartan and Lisinopril may vary depending on factors such as brand, dosage strength, and insurance coverage. Generally, generic versions of both medications are available, which tend to be more affordable than brand-name options. It is advisable to check with your insurance provider or local pharmacy to compare prices and determine the most cost-effective option for you.


Before starting Losartan or Lisinopril, inform your healthcare provider about any pre-existing medical conditions, allergies, or medications you are taking. Certain medical conditions, such as kidney or liver disease, may require caution or dosage adjustments. Additionally, pregnant or breastfeeding individuals should consult their doctor before using either medication, as they may pose risks to the developing fetus or nursing baby.

Which one should you choose?

The choice between Losartan and Lisinopril ultimately depends on various factors, including your medical history, individual response, and potential side effects. It is essential to work closely with your healthcare provider to determine the most suitable medication for managing your blood pressure. Your doctor will consider your specific needs and tailor the treatment accordingly.

In conclusion, both Losartan and Lisinopril are effective medications for managing hypertension. They belong to the same class of drugs but work through different mechanisms to lower blood pressure. While they share similarities in terms of effectiveness, there are differences in side effects, dosage, and cost. Consulting with your healthcare provider is crucial to make an informed decision and ensure the optimal management of your blood pressure.

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