Feb 14, 2024



Weight Management: Who Can Take Naltrexone For Weight Loss?


Always seek advice from your healthcare provider before commencing any new medication regimen.

Naltrexone, often prescribed for opioid and alcohol addiction, has also shown effectiveness in assisting in weight loss, especially when paired with bupropion (Contrave) and lifestyle changes. This guide provides insight into naltrexone's role in weight management, explaining its mechanism, suitable candidates for this treatment, and methods to optimize its benefits.

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Understanding Naltrexone's Mechanism in Weight Loss

Naltrexone's effectiveness in weight loss is attributed to its action on brain regions that regulate appetite. It binds to opioid receptors, reducing the release of dopamine and the desire to overeat. It also influences hormones like ghrelin and leptin, key players in appetite and metabolism regulation. The combination of naltrexone with bupropion, an antidepressant, further enhances its effectiveness by curbing the rewarding effects of food, making it particularly useful for emotional eaters.

Who Can Benefit From Naltrexone in Weight Management

Naltrexone is a potential option for individuals struggling with obesity who haven't achieved weight loss through diet and exercise alone. It's especially suitable for those with a history of opioid or alcohol addiction, as it can help manage cravings and prevent relapse. However, it's not recommended for people with liver disease or for pregnant or breastfeeding women. Always consult a healthcare professional to evaluate whether naltrexone is appropriate for your situation.

Dosage and Side Effects

The dosage for weight loss varies, with common prescriptions ranging from 50 mg to 100 mg daily. Side effects are generally mild, such as dizziness, headache, or gastrointestinal discomfort. In rare cases, serious side effects like depression or liver damage may occur. Adherence to prescribed dosages and monitoring by a healthcare provider can mitigate these risks.

Maximizing the Benefits of Naltrexone With CareCard

Enhancing the effectiveness of naltrexone for weight loss involves a multifaceted approach. Adherence to medication, coupled with a healthy diet and regular exercise, is crucial. Monitoring progress, joining support groups, and working closely with healthcare professionals can further bolster the treatment's success. CareCard plays a pivotal role by making naltrexone more affordable, removing financial barriers to accessing this treatment.


Naltrexone, particularly when used with bupropion, offers a viable strategy for managing obesity and promoting weight loss. With the cost-saving benefits of CareCard and a commitment to lifestyle changes and medical guidance, individuals can effectively pursue their weight management goals.


What is naltrexone?

Naltrexone is a medication primarily used to treat opioid and alcohol addiction, but it has also been found effective in aiding weight loss when combined with other treatments.

How does naltrexone aid in weight loss?

Naltrexone may work by affecting appetite-regulating areas of the brain and decreasing the release of dopamine-related to food rewards. It may also impact hormones that regulate appetite and metabolism.

Who is a suitable candidate for weight loss treatment with naltrexone?

Naltrexone for weight loss is generally recommended for individuals who are overweight or obese and have not achieved significant weight loss through diet and exercise alone.

Can naltrexone be used in combination with other medications for weight loss?

Yes, naltrexone is often prescribed in combination with the antidepressant bupropion in a formulation known as Contrave.

What are the common side effects of Naltrexone?

Common side effects include dizziness, headache, anxiety, insomnia, fatigue, constipation, diarrhea, chills, and muscle pain. Serious side effects can occur but are less common

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