Trazodone: Uses, Warnings, and Side Effects

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Trazodone is a widely used medication primarily prescribed to treat major depressive disorder (MDD). It belongs to a class of medications called serotonin receptor antagonists and reuptake inhibitors (SARIs). While it shares some similarities with selective serotonin reuptake inhibitors (SSRIs), trazodone has distinct mechanisms of action, making it unique in its ability to address depression and related conditions.

This article covers everything you need to know about trazodone, including its uses, dosage, potential side effects, and important safety considerations.

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What Is Trazodone Used For?

Trazodone is mainly prescribed to treat major depressive disorder (MDD). It works by restoring the balance of serotonin, a neurotransmitter in the brain, which can improve mood, appetite, energy levels, and sleep.

In addition to its primary use, trazodone may also be prescribed for:

• Anxiety disorders

• Insomnia (particularly when related to depression)

• Post-traumatic stress disorder (PTSD)

Trazodone is often favored for its sedative properties, which make it a suitable option for those struggling with sleep disturbances caused by depression.

Important Warnings and Precautions

Before taking trazodone, it’s crucial to be aware of potential risks and interactions:

1. Suicidal Thoughts:

   • Young adults and adolescents may experience an increased risk of suicidal thoughts when starting antidepressants. Regular monitoring by a healthcare provider is essential during the first few months of treatment.

2. Allergic Reactions:

   • Do not take trazodone if you are allergic to it or any of its ingredients. Signs of an allergic reaction include hives, difficulty breathing, and swelling of the face or throat.

3. MAO Inhibitor Interactions:

   • Avoid taking trazodone if you’ve used an MAO inhibitor in the past 14 days, as dangerous drug interactions may occur.

4. Serotonin Syndrome:

   • Combining trazodone with other medications that affect serotonin levels (e.g., SSRIs, tramadol, or St. John's wort) can cause serotonin syndrome, a life-threatening condition. Symptoms include agitation, hallucinations, rapid heart rate, and muscle stiffness.

5. Heart Conditions:

   • Trazodone may not be safe for individuals with a history of heart disease, long QT syndrome, or recent heart attacks.

6. Pregnancy and Breastfeeding:

   • Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding. While stopping the medication may not be safe, trazodone could potentially harm the baby.

Dosage and Administration

Trazodone should always be taken as directed by your doctor. The typical starting dose for adults with depression is:

• Initial Dose: 150 mg per day in divided doses.

• Adjustments: Dosage may be increased by 50 mg per day every 3–4 days, based on response and tolerance.

• Maximum Dosage:

  • Outpatients: 400 mg/day.

  • Inpatients: 600 mg/day.

To reduce side effects like drowsiness, many people take the largest portion of their dose at bedtime.

Key Points:

• Take trazodone with food or a light snack to enhance absorption.

• Do not stop taking trazodone abruptly to avoid withdrawal symptoms.

Potential Side Effects

Like all medications, trazodone can cause side effects. While many are mild, some may require immediate medical attention.

Common Side Effects:

• Drowsiness or fatigue

• Dizziness

• Blurred vision

• Nausea or constipation

• Weight changes

Serious Side Effects (contact a doctor immediately):

• Painful or prolonged erections (lasting 6+ hours)

• Fast or irregular heartbeat

• Unusual bleeding or bruising

• Severe dizziness or fainting

• Signs of serotonin syndrome (e.g., fever, agitation, hallucinations)

What to Avoid While Taking Trazodone:

• Alcohol: Combining trazodone with alcohol can cause dangerous sedation or breathing problems.

• Hazardous Activities: Avoid driving or operating machinery until you know how trazodone affects you.

Drug Interactions

Trazodone interacts with many medications, which may increase side effects or reduce its effectiveness. Inform your doctor about all prescription, over-the-counter, and herbal products you are taking, including:

• Other antidepressants (e.g., SSRIs, SNRIs)

• Opioid medications

• Migraine treatments (e.g., sumatriptan)

• Blood thinners (e.g., warfarin)

• Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen

Using a Prescription Discount Card

Prescription costs for medications like trazodone can vary widely. A prescription discount card can help you save significantly on your medication costs. CareCard provides free discount cards that are accepted at pharmacies nationwide.

Learn more about how a prescription discount card can help you save on trazodone and other medications by visiting CareCard.

Conclusion

Trazodone is a versatile and widely prescribed medication for managing depression, anxiety, and sleep disturbances. Its sedative effects and unique action on serotonin make it a valuable option, especially for individuals who have not responded well to other treatments. While generally well-tolerated, it's important to be aware of potential side effects and drug interactions—and to take trazodone exactly as prescribed.

To help manage the cost of your prescription, consider using a free prescription discount card from CareCard. It’s easy to use and can offer significant savings at pharmacies near you.

For more information on mental health medications and how to save on prescriptions, explore helpful tools and resources available through CareCard.

Frequently Asked Questions

What happens if I miss a dose of trazodone?

If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double up.

How long does trazodone take to work?

Trazodone may take 1–2 weeks to start improving symptoms. Full effects can take up to 4–6 weeks.

Is trazodone addictive?

Trazodone is not considered addictive but may cause withdrawal symptoms if stopped suddenly. Always taper off under a doctor’s supervision.

Can trazodone be used long-term?

Yes, trazodone is often used long-term for depression or insomnia, provided it remains effective and side effects are manageable.

How can I save money on trazodone?

Using a prescription discount card from CareCard can reduce out-of-pocket costs for trazodone.